Global Macroeconomic Challenges in the Digital Era give rise to new dynamics in world economic interactions. Digital transformation has changed the way businesses operate, creating its own challenges for governments and economic actors. One of the main challenges is economic uncertainty caused by global market fluctuations. Increases and decreases in currency exchange rates can affect investment and international trade, resulting in a direct impact on the economic growth of developing countries. Furthermore, the adoption of digital technology creates an access gap between developed and developing countries. Countries that do not have adequate digital infrastructure face difficulties in competing in the global market. This creates the risk of economic inequality, where more developed countries continue to benefit, while other countries are trapped in a cycle of poverty. Expanding internet access and investment in information technology are important steps to overcome this problem. Then, the world of work also experienced a significant transformation due to automation and digitalization. Many traditional jobs are threatened with extinction, while the need for digital skills is increasing. Therefore, education and retraining are vital to prepare the workforce to face these new challenges. Companies and governments need to collaborate to create programs that are relevant and able to meet market demands. Another issue that is no less important is the rules and regulations that follow the development of digitalization. Many countries do not yet have an adequate legal framework to regulate digital business, including data privacy and cybersecurity. This creates loopholes that can be exploited by negative actors, threatening global economic stability. Developing adaptive policies is important to support innovation while maintaining the security and integrity of the economic system. Technological innovations such as blockchain and artificial intelligence (AI) open up new opportunities, but also create risks for the global economy. For example, cryptocurrencies offer an alternative to the financial system, but they can disrupt traditional markets and carry the risk of high volatility. Clear and wise regulations need to be implemented to minimize potential negative impacts. Additionally, environmental challenges are becoming increasingly pressing in the digital era. Digitalization has an impact on energy consumption and carbon emissions. Combining green technology and digitalization can help countries face the issue of climate change, but requires significant commitment and investment from all stakeholders. In facing global macroeconomic challenges in the digital era, international collaboration is crucial. Countries need to work together to share knowledge and resources. International forums, such as the G20 and other organizations, should be convened to develop inclusive and sustainable global guidelines. Accepting this challenge, innovation and adaptation are the keys to taking advantage of the opportunities offered by the digital era. Countries that are able to provide technological and educational support will have a stronger position in the ever-changing global economy. The balance between economic growth and social responsibility must continue to be maintained to achieve inclusive and sustainable results.